by Dr Dan Plews

As we have discussed in several previous blogs, and in our courses, adaptations to endurance training are produced through activation of cellular signalling pathways in response to individual training sessions, with these cellular signalling pathways activated through detection of the physiological stresses generated through exercise. In this blog, we are going to focus on one of the most well-known proteins in the adaptive signalling cascade, the cellular energy sensor AMPK.

AMPK, or to give its full name, 5’adenosine monophosphate-activated protein kinase, is an important protein in the detection of the cellular energy stresses generated during endurance exercise (1). Specifically, AMPK within the muscle is activated by the metabolic stresses generated by exercise, and subsequently activates signalling pathways associated with endurance training adaptation (2). This pathway makes a lot of sense; if our muscle is stressed by exercise, we detect it and then...